Ramatroban
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3213758 | Sigma-Aldrich | 25 MG | 6860 | 请咨询 |
| 3213758 | Sigma-Aldrich | 5 MG | 1980 | 请咨询 |
| 4006223 | TCI | 10MG | 1138 | 请咨询 |
| 4006223 | TCI | 50MG | 3280 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C21H21FN2O4S |
| Molecular weight | 416.47 |
| MDL number | MFCD00887606 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823986 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Ramatroban is used for the treatment of allergic rhinitis as an antagonist of the thromboxane receptor. It is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM. It is more potent at the DP2 receptor than the TP receptor by 4-5 fold. It is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type. Ramatroban aids in the reduction of myocardial ischemia-reperfusion injury, lipopolysaccharide-induced shock, and vagal neuroeffector transmission in the tracheal smooth muscle of experimental models. In addition, it also suppresses allergen and IgE antibody-mediated skin and nasal reactions and eosinophilia in animal models with asthma. |
| Features and Benefits【特点和优势】 | This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: ≥40 mg/mL H2O: insoluble |
| originator【创始人】 | Bayer |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC(=O)CCn1c2CC[C@H](Cc2c3ccccc13)NS(=O)(=O)c4ccc(F)cc4 |
| InChI | 1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1 |
| InChI key | LDXDSHIEDAPSSA-OAHLLOKOSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |