GSK2578215A
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3094046 | Sigma-Aldrich | 5 MG | 1630 | 请咨询 |
| 3094046 | Sigma-Aldrich | 25 MG | 4550 | 请咨询 |
| 4007739 | J&K | 5MG | 611 | 请咨询 |
| 4007739 | J&K | 10MG | 863 | 请咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H18FN3O2 |
| Molecular weight | 399.42 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | GSK2578215A stimulates mitochondrial fragmentation, autophagy and mitophagy. GSK2578215A is a potent inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson′s disease. Because the most common mutation, G2019S, enhances LRRK2 kinase activity, it is hoped that LRRK2 inhibitors may be useful in treating the disease. GSK2578215A inhibited both wild-type and G2019S mutant LRRK2 kinase activity with IC50s of 10.9 and 8.9 nM respectively. It has good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 15 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |