ETP-46464
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3086389 | Sigma-Aldrich | 5 MG | 1530 | 请咨询 |
| 4007291 | J&K | 5MG | 1170 | 请咨询 |
| 4007291 | J&K | 10MG | 1930 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C30H22N4O2 |
| Molecular weight | 470.52 |
| MDL number | MFCD23160051 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825784 |
| Biochem/physiol Actions【生化/生理作用】 | ETP-46464 is a potent and selective inhibitor of the DNA damage response kinase Ataxia telangiectasia-mutated (ATM) - and Rad3-related (ATR) with an IC50 of 25 nM. ETP-46464 shows moderate activity against PI3K and is a potent inhibitor of mTor, but is selective for ATR versus ATM and DNA -dependent protein kinase (DNA -PKcs) even at high doses. ETP-46464 inhibited phosphorylation of Chk1, the downstream kinase of ATR, but did not affect ionizing radiation–induced γH2AX formation, which is jointly controlled by ATM and DNA-PKc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to light brown |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC(C)(C#N)C(C=C1)=CC=C1N(C2=C(CO3)C=NC(C2=C4)=CC=C4C5=CC6=C(C=CC=C6)N=C5)C3=O |
| InChI | 1S/C30H22N4O2/c1-30(2,18-31)23-8-10-24(11-9-23)34-28-22(17-36-29(34)35)16-33-27-12-7-19(14-25(27)28)21-13-20-5-3-4-6-26(20)32-15-21/h3-16H,17H2,1-2H3 |
| InChI key | DPLMXAYKJZOTKO-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |