Ro-32-0432-CAS 145333-02-4-Calbiochem

C₂₈H₂₈N₄O₂ · xHCl

452.55 (free base basis)

A selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKC_α (IC₅₀ = 9 nM) and 4-fold greater selectivity for PKC_βI (IC₅₀ = 28 nM) over PKC_ε (IC₅₀ = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A selective cell-permeable protein kinase C inhibitor. Displays about a 10-fold greater selectivity for PKC_α (IC₅₀ = 9 nM) and a 4-fold greater selectivity for PKC_βI (IC₅₀ = 28 nM) over PKC_ε (IC₅₀ = 108 nM). Also prevents T-cell driven chronic inflammatory responses in vivo.

Cell permeable: yes
Primary Target
PKCα
Target IC₅₀: 9 nM, 28 nM, 108 nM, against PKCα, PKCβI, and PKCε, respectively
Product does not compete with ATP.
Reversible: no

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther.268, 922.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

red

DMSO: 5 mg/mL

ambient

2-8℃

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 3