雷尼司他
Ranirestat
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3213773 | Sigma-Aldrich | 5 MG | 2480 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C17H11BrFN3O4 |
| Molecular weight | 420.19 |
| MDL number | MFCD00920915 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825780 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D -5 to -10°, c = 1.0 in methanol |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O |
| InChI | 1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1 |
| InChI key | QCVNMNYRNIMDKV-QGZVFWFLSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |