亚甲基二磷酸四乙酯

Tetraethyl methylidenediphosphonate is used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters. It acts as an intermediate for the synthesis of bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity. It is also used as a reactant for synthesis of dual substrate-site inhibitors of 3-deoxy-D-arabino-heputosonate 7-phosphate synthase and alpha-amino acid derivatives containing gem-biophosphonates, Lycopene through Wittig-Horner reaction. It is also used as a precursor for the preparation of dendritic polyglycerol anions.

Incompatible with strong oxidizing agents.

MFCD00039887

216-764-5

C₉H₂₂O₆P₂

288.22

151-153°/1.2mm

>110°(230°F)

1.162

1.4400

Ambient temperatures.

Liquid

Slightly miscible with water.

1813241

36/38
Irritating to eyes and skin.

26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

SZ9150000

是

 

H315-H319
Causes skin irritation.Causes serious eye irritation.

P280g-P305+P351+P338
Wear protective gloves.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.