GSK3787
| CAS NO： | 188591-46-0 |
| 规格： | ≥98% (HPLC), white to off-white, powder |
| 包装规格： | 5 MG，10MG，50MG，10 MG，100mg，500mg |
| 优惠价： | QQ在线咨询在线留言 |
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3094051 | Sigma-Aldrich | 5 MG | 1750 | 请咨询 |
| 4007287 | J&K | 10MG | 885 | 请咨询 |
| 4007287 | J&K | 50MG | 3290 | 请咨询 |
| 4168606 | Sigma-Aldrich | 10 MG | 2610 | 请咨询 |
| 4176921 | Fluorochem | 100mg | 8000 | 请咨询 |
| 4176921 | Fluorochem | 500mg | 23950 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C15H12ClF3N2O3S |
| Molecular weight | 392.78 |
| MDL number | MFCD00099612 |
| PubChem Substance ID【PubChem化学物质编号】 | 329799963 |
| NACRES | NA.77 |
| Application【应用】 | GSK3787 has been used to inhibit the role of peroxisome proliferator-activated receptor-delta (PPARδ), during the pre-implantation period of bovine embryonic development. It has also been used as a PPARδ-specific inhibitor in in vitro maturation (IVM) media to inhibit PPARδ. |
| Biochem/physiol Actions【生化/生理作用】 | GSK3787 is an orally available selective irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) antagonist (pIC50=6.6) with no measurable affinity for hPPARR or hPPARγ (pIC50<5). It acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells. GSK3787 is known to exhibit pharmacokinetic properties. |
| Features and Benefits【特点和优势】 | This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: ≥10 mg/mL |
| originator【创始人】 | GlaxoSmithKline |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=S(C1=CC=C(C=N1)C(F)(F)F)(CCNC(C2=CC=C(Cl)C=C2)=O)=O |
| InChI | 1S/C15H12ClF3N2O3S/c16-12-4-1-10(2-5-12)14(22)20-7-8-25(23,24)13-6-3-11(9-21-13)15(17,18)19/h1-6,9H,7-8H2,(H,20,22) |
| InChI key | JFUIMTGOQCQTPF-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |