JIB-04
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3102167 | Sigma-Aldrich | 5 MG | 1600 | 请咨询 |
| 3102167 | Sigma-Aldrich | 25 MG | 4510 | 请咨询 |
| 4009629 | J&K | 10MG | 1070 | 请咨询 |
| 4009629 | J&K | 50MG | 2870 | 请咨询 |
| 4176342 | Fluorochem | 10mg | 2900 | 请咨询 |
| 4176342 | Fluorochem | 250mg | 10400 | 请咨询 |
| 4176342 | Fluorochem | 1g | 19730 | 请咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H13ClN4 |
| Molecular weight | 308.76 |
| NACRES | NA.77 |
| Application【应用】 | JIB-04 has been used in sulforhodamine B cell growth assay. It has also been used as a control to determine the inhibitory action of ML324 on KDM4A (histone lysine demethylase 4A). |
| Biochem/physiol Actions【生化/生理作用】 | JIB-04 is a selective inihibitor of Jumonji demethylases without inhibiting other α-ketoglutarate-dependent hydroxylases or histone-modifying enzymes including amine oxidase LSD1 (also known as KDM1A), which demethylates histone lysines. JIB-04 is a pan-inhibitor of Jumonji demethylases with JARID1A (KDM5A) being the most sensitive (IC50=230 nM) followed by JMJD2D (IC50=290 nM) and JMJD3 (KDM6B) and JMJD2C (KDM4C) more resistant (IC50 855 and 1100 nM, respectively). JIB-04 selectively inhibited viability of several human cancer cell lines with little toxicity towards normal cells, and also diminished tumor growth in two separate xenograft mouse models. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |