丙酰-L-肉碱

C₁₀H₁₉NO₄

217.26

MFCD00870024

329756246

NA.26

Propionyl-L-carnitine (PLC) is a short-chain fatty acid ester derivative of carnitine.

Propionyl-L-carnitine has been used as a standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation. PLC has the potential to treat severe peripheral arterial disease and chronic heart failure. It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.

100

≥94.0% (HPLC)

powder or crystals

[α]/D -23±3°, c = 1 in H₂O

LC/MS: suitable

≤10% water (calcd. from elemental analysis)

white to off-white

2-8℃

[O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O

1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1

UFAHZIUFPNSHSL-MRVPVSSYSA-N

13 - Non Combustible Solids

WGK 3