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FM19G11

CAS NO：

规格：	≥98% (HPLC)

包装规格：

5 MG，25 MG

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产品价格

产品编号	品牌	包装单位	单价(元)	现货
3088239	Sigma-Aldrich	5 MG	1750	请咨询
3088239	Sigma-Aldrich	25 MG	6410	请咨询

结构式

基本信息

Empirical Formula【经验(实验)分子式】	C₂₃H₁₇N₃O₈
Molecular weight	463.40
MDL number	MFCD01174289
PubChem Substance ID【PubChem化学物质编号】	329799774
NACRES	NA.77
Application【应用】	FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α): to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
Biochem/physiol Actions【生化/生理作用】	FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.

产品性质

Quality Level【质量水平】	100
Assay【测定】	≥98% (HPLC)
form【形式】	powder
color【颜色】	off-white to light brown
solubility【溶解性】	DMSO: ≥40 mg/mL
storage temp.【储存温度】	2-8℃
SMILES string	Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2
InChI	1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)
InChI key	XVUOIWIIQVGWAJ-UHFFFAOYSA-N
packaging【包装】	5, 25 mg in glass bottle

安全信息

Storage Class Code【储存分类代码】	11 - Combustible Solids
WGK	WGK 3

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