产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3097099 | Sigma-Aldrich | 5 MG | 1220 | 请咨询 |
| 3097099 | Sigma-Aldrich | 25 MG | 4490 | 请咨询 |
| 4156698 | Sigma-Aldrich | 10 MG | 1870 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C25H25N3O2 |
| Molecular weight | 399.48 |
| MDL number | MFCD02168344 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825752 |
| NACRES | NA.77 |
| Application【应用】 | HLM006474 has been used as an E2 factor (E2F) inhibitor in human nasopharyngeal carcinoma hone-1 cells and T. annulata-infected TBL20 cells. |
| Biochem/physiol Actions【生化/生理作用】 | HLM006474 is a pan-E2F transcription factor inhibitor. E2F s part of the CDK/Rb/E2F pathway. When phosphorylated by CDKs, the tumor suppressor retinoblastoma protein (Rb) is inactivated, releasing E2Fs and allowing cell cycle progression. HLM006474 inhibited DNA-binding of all E2F complexes and down-regulated expression of E2F4 protein. HLM006474 induced apoptosis of A375 melanoma cells and synergized with paclitaxel in lung cancer cell lines. HLM006474 activates p53 and induces DNA damage and apoptosis in mouse tumor models. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1=CC(C(NC2=NC=CC=C2)C3=C(O)C(N=C(C)C=C4)=C4C=C3)=CC=C1OCC |
| InChI | 1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28) |
| InChI key | CYNZBLNMIJNBSF-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |