介藜芦胺

Jervine
CAS NO:469-59-0
规格:≥98% (HPLC), powder
包装规格:1 MG,1MG,5MG,10MG,20mg
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产品价格
产品编号品牌包装单位单价(元)现货
3102161Sigma-Aldrich1 MG2020请咨询
3502670J&K1MG387请咨询
3502670J&K5MG1410请咨询
3528965J&K10MG2550请咨询
3991897CATO20mg询价请咨询
4010244J&K20MG4240请咨询
4181919Fluorochem10mg3430请咨询
结构式
基本信息
Empirical Formula【经验(实验)分子式】
C27H39NO3
Molecular weight
425.60
EC number【EC 号】
207-417-9
MDL number
MFCD01684066
PubChem Substance ID【PubChem化学物质编号】
24896194
NACRES
NA.77
General description【一般描述】
Jervine is a steroid alkaloid present in Veratrum californicum.
Biochem/physiol Actions【生化/生理作用】
Jervine is a potent teratogenic agent. It can induce apoptosis in leukemia cells and MUTZ-1 cells. Jervine is an inhibitor of Hedgehog signaling. It exhibits anti-cancer effects on human prostate cancer. It also increases the chemosensitivity of breast cancer cells to doxorubicin treatment. Jervine may be used for treating hypertension and heart disease.
Jervine is a sonic hedgehog (Shh) pathway inhibitor.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
solubility【溶解性】
methanol: >2 mg/mL
H2O: insoluble
storage temp.【储存温度】
−20℃
SMILES string
[H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(=C3C)C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)O2
InChI
1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
InChI key
CLEXYFLHGFJONT-DNMILWOZSA-N
Gene Information
human ... EBP(10682)
packaging【包装】
1 mg in glass bottle
安全信息
Pictograms【象形图】
GHS06,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H301 - H360D
Precautionary Statements
P201 - P301 + P310 + P330
Hazard Classifications【危险分类】
Acute Tox. 3 Oral - Repr. 1B
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 1
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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