EVP4593

CAS NO:545380-34-5
规格:≥98% (HPLC)
包装规格:5 MG,25 MG,5MG,25MG,1 MG,250mg,1g
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产品价格
产品编号品牌包装单位单价(元)现货
3086511Sigma-Aldrich5 MG1650请咨询
3086511Sigma-Aldrich25 MG6060请咨询
4006221TCI5MG908请咨询
4006221TCI25MG2950请咨询
4010414J&K5MG724请咨询
4063814Sigma-Aldrich1 MG2090请咨询
4185748Fluorochem250mg5740请咨询
4185748Fluorochem1g14300请咨询
结构式
基本信息
Empirical Formula【经验(实验)分子式】
C22H20N4O
Molecular weight
356.42
MDL number
MFCD06411436
PubChem Substance ID【PubChem化学物质编号】
329825563
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.
Features and Benefits【特点和优势】
This compound is featured on the Calcium Channels, Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes【其他说明】
Air sensitive
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
storage condition【储存条件】
desiccated
color【颜色】
white to beige
solubility【溶解性】
DMSO: 15 mg/mL, clear
storage temp.【储存温度】
2-8℃
SMILES string
NC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1
InChI
1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
InChI key
IBAKVEUZKHOWNG-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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