Fenobam
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3087089 | Sigma-Aldrich | 5 MG | 1270 | 请咨询 |
| 3087089 | Sigma-Aldrich | 25 MG | 4460 | 请咨询 |
| 4181947 | Fluorochem | 10mg | 1910 | 请咨询 |
| 4181947 | Fluorochem | 50mg | 6490 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C11H11ClN4O2 |
| Molecular weight | 266.68 |
| MDL number | MFCD00868019 |
| PubChem Substance ID【PubChem化学物质编号】 | 24894721 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity. |
| Features and Benefits【特点和优势】 | This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| originator【创始人】 | Johnson & Johnson |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CN1CC(=O)N=C1NC(=O)Nc2cccc(Cl)c2 |
| InChI | 1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18) |
| InChI key | DWPQODZAOSWNHB-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |