产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3102339 | Sigma-Aldrich | 5 MG | 1240 | 请咨询 |
| 4007076 | J&K | 10MG | 914 | 请咨询 |
| 4007076 | J&K | 50MG | 2910 | 请咨询 |
| 4055956 | Alfa Aesar | 100mg | 15570 | 请咨询 |
| 4169512 | Sigma-Aldrich | 25 MG | 3120 | 请咨询 |
结构式
 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H26N2O5 |
| Molecular weight | 434.48 |
| NACRES | NA.77 |
| Application【应用】 | JW55 has been used as a tankyrase-specific inhibitor to study its effects on the transcriptional activity of SRY-related HMG-box gene 9 (Sox9) in chondrocytes. |
| Biochem/physiol Actions【生化/生理作用】 | JW55 is a potent and selective inhibitor of Wnt/β-catenin signaling, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2) leading to stabilization of AXIN2 followed by increased degradation of β-catenin. JW55 specifically inhibits canonical Wnt signaling that results in reduced cell-cycle progression, proliferation, and colony formation in colon carcinoma cell lines. JW55 can decrease the formation of mouse colon adenoma in vivo. It possesses a methoxyphenyl moiety spreading towards the G-loop. |
| Other Notes【其他说明】 | JW55 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JW55 probe summary on the Chemical Probes Portal website. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 15 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |