Gc-球蛋白 来源于人类血浆
Gc-globulin from human plasma
| CAS NO： | 68476-36-8 |
| 规格： | ≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt) |
| 包装规格： | 1 MG，5 G，10 G |
| 优惠价： | QQ在线咨询在线留言 |
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 4074575 | Sigma-Aldrich | 1 MG | 3100 | 请咨询 |
| 4075857 | Sigma-Aldrich | 5 G | 3220 | 请咨询 |
| 4087314 | Sigma-Aldrich | 10 G | 13090 | 请咨询 |
基本信息
| MDL number | MFCD00131143 |
| NACRES | NA.61 |
| General description【一般描述】 | Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3. Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells. Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure. |
| Application【应用】 | Gc-globulin from human plasma has been used:
Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns. |
| Biochem/physiol Actions【生化/生理作用】 | Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells. Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D]. |
| Preparation Note【制备说明】 | Native Gc-globulin from human plasma |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human plasma |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | lyophilized powder (containing sodium chloride and sodium phosphate buffer salt) |
| mol wt【分子量】 | ~52 kDa |
| technique(s) | LC/MS: suitable |
| solubility【溶解性】 | H2O: soluble 2 mg/mL |
| UniProt accession no.【UniProt登记号】 | P02774 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GC(2638) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |