KU-60019
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3103025 | Sigma-Aldrich | 5 MG | 1530 | 请咨询 |
| 3103025 | Sigma-Aldrich | 25 MG | 5620 | 请咨询 |
| 4006856 | J&K | 10MG | 1070 | 请咨询 |
| 4006856 | J&K | 50MG | 3130 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C30H33N3O5S |
| Molecular weight | 547.67 |
| MDL number | MFCD19690944 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825862 |
| NACRES | NA.77 |
| Application【应用】 | KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death. |
| Biochem/physiol Actions【生化/生理作用】 | KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase, a member of phosphatidylinositol-3-kinase-related kinase family that is critical in regulating cell cycle checkpoints and DNA repair. KU-60019 has an IC50 value of 6.3 nM. KU-60019 radiosensitizes U1242 human glioma cells, and also blocks U1242 cell migration and invasion through matrigel. |
| Other Notes【其他说明】 | KU-60019 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the KU-60019 probe summary on the Chemical Probes Portal website. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(CN1C[C@H](C)O[C@H](C)C1)NC(C=C2)=CC3=C2SC4=C(C5=CC(C=C(N6CCOCC6)O5)=O)C=CC=C4C3 |
| InChI | 1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+ |
| InChI key | SCELLOWTHJGVIC-BGYRXZFFSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |