产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3098397 | Sigma-Aldrich | 5 MG | 2980 | 请咨询 |
| 3098397 | Sigma-Aldrich | 10 MG | 5000 | 请咨询 |
| 3514644 | J&K | 5MG | 2700 | 请咨询 |
| 3514644 | J&K | 25MG | 9970 | 请咨询 |
| 4084463 | Sigma-Aldrich | 5 MG | 3800 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C15H8ClF6NO2 |
| Molecular weight | 383.67 |
| MDL number | MFCD00218820 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724513 |
| NACRES | NA.77 |
| Application【应用】 | IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts. |
| Biochem/physiol Actions【生化/生理作用】 | IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4] |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F |
| InChI | 1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25) |
| InChI key | CHILCFMQWMQVAL-UHFFFAOYSA-N |
| packaging【包装】 | 5, 10 mg in glass bottle Light sensitive. Packaged under nitrogen. |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |