PKA Inhibitor 5-24-CAS 99534-03-9-Calbiochem
| CAS NO： | 99534-03-9 |
| 规格： | The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| 包装规格： | 500 μG |
| 优惠价： | QQ在线咨询在线留言 |
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 4096125 | Sigma-Aldrich | 500 μG | 3120 | 请咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C94H148N32O31 |
| Molecular weight | 2222.38 |
| MDL number | MFCD00133989 |
| General description【一般描述】 | A potent synthetic peptide that is a competitive inhibitor of protein kinase A (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate. Peptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (Ki = 2.3 nM). |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: no Cell permeable: no Target Ki: 2.3 nM for protein kinase A |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH |
| Preparation Note【制备说明】 | Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization. |
| Other Notes【其他说明】 | Knighton, D.R., et al. 1991. Science 253, 525. Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989. Rusine, T., et al. 1986. J. Cell Biol.102, 1630. Wong, Y.S., et al. 1986. J. Biol. Chem..261, 12089. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| solubility【溶解性】 | water: 1 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C94H148N32O31/c1-11-42(3)70(124-85(150)58(31-50-19-14-13-15-20-50)117-84(149)61(35-67(135)136)116-74(139)44(5)110-81(146)57(32-51-24-26-53(131)27-25-51)119-90(155)73(49(10)130)126-86(151)69(96)47(8)128)88(153)112-45(6)75(140)122-63(40-127)77(142)107-38-65(133)114-55(22-17-29-105-93(99)100)80(145)125-72(48(9)129)87(152)108-39-66(134)113-54(21-16-28-104-92(97)98)78(143)115-56(23-18-30-106-94(101)102)79(144)118-60(34-64(95)132)82(147)111-46(7)76(141)123-71(43(4)12-2)89(154)120-59(33-52-37-103-41-109-52)83(148)121-62(91(156)157)36-68(137)138/h13-15,19-20,24-27,37,41-49,54-63,69-73,127-131H,11-12,16-18,21-23,28-36,38-40,96H2,1-10H3,(H2,95,132)(H,103,109)(H,107,142)(H,108,152)(H,110,146)(H,111,147)(H,112,153)(H,113,134)(H,114,133)(H,115,143)(H,116,139)(H,117,149)(H,118,144)(H,119,155)(H,120,154)(H,121,148)(H,122,140)(H,123,141)(H,124,150)(H,125,145)(H,126,151)(H,135,136)(H,137,138)(H,156,157)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)/t42-,43-,44-,45-,46-,47?,48?,49?,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,69-,70-,71-,72-,73-/m0/s1 |
| InChI key | AXOXZJJMUVSZQY-BVDKBYOBSA-N |
| packaging【包装】 | 500 μg in Plastic ampoule Yes |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |