ML-9
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3139118 | Sigma-Aldrich | 5 MG | 1770 | 请咨询 |
| 4176539 | Fluorochem | 250mg | 16120 | 请咨询 |
结构式
 |
基本信息
| Linear Formula【线性分子式】 | C15H17N2O2SCl · HCl |
| Molecular weight | 361.29 |
| MDL number | MFCD00065525 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278297 |
| NACRES | NA.77 |
| Application【应用】 | ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells. |
| Biochem/physiol Actions【生化/生理作用】 | ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes. |
| Features and Benefits【特点和优势】 | This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | synthetic (organic) |
| Assay【测定】 | ≥99% (TLC) |
| form【形式】 | powder |
| color【颜色】 | white |
| solubility【溶解性】 | ethanol: 10 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3 |
| InChI | 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H |
| InChI key | ZNRYCIVTNLZOGI-UHFFFAOYSA-N |
| Gene Information | human ... SLC2A1(6513), SLC2A4(6517) |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |