产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3180626 | Sigma-Aldrich | 25 MG | 4490 | 请咨询 |
| 3180626 | Sigma-Aldrich | 5 MG | 1220 | 请咨询 |
| 3540334 | Echelon | 10mg | 2350 | 请咨询 |
| 3540334 | Echelon | 1mg | 676 | 请咨询 |
| 4155199 | Sigma-Aldrich | 10 MG | 3350 | 请咨询 |
结构式
 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H21Cl2N3O5 |
| Molecular weight | 478.33 |
| NACRES | NA.77 |
| Application【应用】 | PF-8380 has been used in biological assays. It has also been used to estimate the role of intestinally-derived lysophosphatidic acid in dyslipidemia and atherosclerosis. |
| Biochem/physiol Actions【生化/生理作用】 | PF-8380 [6-(3-(piperazin-1-yl)propanoyl)benzo[d]oxazol-2(3H)-one] has the ability to change the resistant and invasive features of glioblastoma and helps to improve the response to radiation therapy. PF-8380 is a potent orally bioavailable inhibitor of autotaxin (ATX), the enzyme that synthesize lysophosphatidic acid (LPA) from lysophosphatidyl choline, and is an emerging target for treatment of inflammatory conditions, including cancer, arthritis and multiple sclerosis. PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |