ML133 盐酸盐
ML133 hydrochloride
产品价格
| 产品编号 | 品牌 | 纯度规格 | 包装单位 | 单价(元) | 现货 |
| 3139122 | Sigma-Aldrich | ≥95% (HPLC) | 25 MG | 4770 | 请咨询 |
| 3139122 | Sigma-Aldrich | ≥95% (HPLC) | 5 MG | 1620 | 请咨询 |
| 3462239 | 韶远 | 95+% | 0.25g | 753 | 请咨询 |
| 3462239 | 韶远 | 95+% | 1g | 1790 | 请咨询 |
| 3462239 | 韶远 | 95+% | 5g | 4890 | 请咨询 |
结构式
 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H19NO · HCl |
| Molecular weight | 313.82 |
| MDL number | MFCD20921521 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825217 |
| NACRES | NA.77 |
| Application【应用】 | ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity. ML133 hydrochloride may be used to study cell signaling that involves the function of potassium channels. |
| Biochem/physiol Actions【生化/生理作用】 | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters. |
| Features and Benefits【特点和优势】 | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥10 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.COc1ccc(CNCc2cccc3ccccc23)cc1 |
| InChI | 1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H |
| InChI key | NGQIBUUFXDPHKT-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05,GHS07,GHS09 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H315 - H318 - H335 - H400 |
| Precautionary Statements | P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |