MS-1020
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3155322 | Sigma-Aldrich | 25 MG | 4770 | 请咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H18N2O3 |
| Molecular weight | 346.38 |
| NACRES | NA.77 |
| Application【应用】 | MS-1020 may be used in JAK-3-mediated cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression. |
| Features and Benefits【特点和优势】 | This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥10 mg/mL at 60 ℃ |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H319 |
| Precautionary Statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |