DL-α-Tocopherol methoxypolyethylene glycol succinate

NA.22

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product TPGS-750-M is a lead surfactant for many transition metal-catalyzed cross-couplings and has been enhanced for catalytic efficiency. Find details here.
Learn More at the Professor and Product Portal of Professor Bruce Lipshutz.

DL-α-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M), a biodegradable and water-soluble derivative of natural vitamin E, is used as an environmentally benign nonionic surfactant in metal-catalyzed cross-coupling reactions in water. It is used in Heck, Suzuki-Miyaura, Sonogashira, and Negishi like couplings reactions. It can also be utilized in aminations, C-H activations, and olefin metathesis reactions.
TPGS-750-M can also be employed in:

• The nucleophilic aromatic substitution reaction of aryl and heteroaryl halides with nitrogen, oxygen, and sulfur nucleophiles under mild conditions.
• The preparation of quinoxaline-2,3 diones from quinoxalinones via C(sp²)-H hydroxylation reaction.
• The intramolecular N-arylation of amines using a copper catalyst.

On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors

Watch Professor Lipshutz talk about TPGS-750-M in this webinar:
From milligrams to kilograms: synthetic chemistry following nature′s lead

reagent type: catalyst
reaction type: C-H Activation
reagent type: surfactant

100

Catalysis
Learn more about the Principles of Green Chemistry.

T_m 29-34

Aligned

1, 10, 25 g in glass bottle

11 - Combustible Solids

WGK 3