ML218
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3139131 | Sigma-Aldrich | 5 MG | 2020 | 请咨询 |
结构式
 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H26Cl2N2O |
| Molecular weight | 369.33 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825385 |
| NACRES | NA.77 |
| Application【应用】 | ML218 has been used as a:
|
| Biochem/physiol Actions【生化/生理作用】 | ML218 (CID 45115620) is a potent and selective T-Type (Cav3.1, Cav3.2, Cav3.3) calcium channel inhibitor (Cav3.2, IC50 = 150 nM in Ca2+ flux; Cav3.2 IC50 = 310 nM and Cav3.3 IC50 = 270 nM with good Drug metabolism/Pharmacokinetics. In a panel of 68 GPCRs, ion channels and transporters, ML218 was found to bind significantly only two other targets (sodium channel site 2 and sigma 1) and had no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. It showed robust inhibition of calcium current in STN neurons and was orally active in a rodent model of Parkinson′s Disease. |
| Features and Benefits【特点和优势】 | This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL (clear solution) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(C)(C)CCN1C[C@H]2C(CNC(=O)c3cc(Cl)cc(Cl)c3)[C@H]2C1 |
| InChI | 1S/C19H26Cl2N2O/c1-19(2,3)4-5-23-10-16-15(17(16)11-23)9-22-18(24)12-6-13(20)8-14(21)7-12/h6-8,15-17H,4-5,9-11H2,1-3H3,(H,22,24)/t15-,16-,17+ |
| InChI key | GSJIGYLGKSBYBC-OSYLJGHBSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |