Oxamflatin

C₁₇H₁₄N₂O₄S

342.37

MFCD00949087

329818905

NA.77

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:

• to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
• to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
• to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
• to study its stand-alone effect on cytarabine-sensitive and resistant cells.

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.
Histone deacetylase inhibitor; anti-cancer agent.

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100

≥98% (HPLC)

solid

DMSO: soluble 13 mg/mL

2-8℃

ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1

1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+

QRPSQQUYPMFERG-LFYBBSHMSA-N

1, 5 mg in glass bottle

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)