Lomitapide
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3106175 | Sigma-Aldrich | 25 MG | 6760 | 请咨询 |
| 3106175 | Sigma-Aldrich | 5 MG | 2310 | 请咨询 |
| 4005379 | TCI | 100MG | 1138 | 请咨询 |
| 4005379 | TCI | 25MG | 348 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C39H37F6N3O2 |
| Molecular weight | 693.72 |
| MDL number | MFCD16620494 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825833 |
| NACRES | NA.77 |
| Application【应用】 | Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes. |
| Biochem/physiol Actions【生化/生理作用】 | Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia. Lomitapide can lower the secretion of very-low-density lipoproteins (VLDL) and chylomicrons. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O |
| InChI | 1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49) |
| InChI key | MBBCVAKAJPKAKM-UHFFFAOYSA-N |
| Gene Information | human ... MTTP(4547), P4HB(5034) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |