CP-101606 甲磺酸酯

C₂₀H₂₅NO₃ · CH₄O₃S

423.52

MFCD12546332

329823794

NA.77

CP-101606 mesylate (Traxoprodil mesylate) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. CP-101606 mesylate has been shown to be neuroprotective in animal models of brain injury and stroke.
CP-101,606 is an NR2B (N-methyl D-aspartate receptor subtype 2B) subunit antagonist, that can increase dyskinesia. It reduces Ca²⁺/calmodulin-dependent protein kinase II level, at threonine-286 hyperphosphorylation (pCaMKII-Thr286). It has no effect on the α1-adrenergic receptors. CP-101,606 has the ability to inhibits the habits, stimulated by cocaine. It also possesses hallucinogenic properties.

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

100

≥98% (HPLC)

powder

Pfizer^®

white to beige

DMSO: 20 mg/mL, clear

Pfizer

room temp

OC1=CC=C([C@H](O)[C@H](C)N2CCC(O)(C3=CC=CC=C3)CC2)C=C1.CS(=O)(O)=O

1S/C20H25NO3.CH4O3S/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17;1-5(2,3)4/h2-10,15,19,22-24H,11-14H2,1H3;1H3,(H,2,3,4)/t15-,19+;/m0./s1

OZBWUANKVIMZIA-WRRDZZDISA-N

5, 25 mg in glass bottle

GHS06,GHS09

Danger

H301 - H319 - H400

P273 - P301 + P310 + P330 - P305 + P351 + P338

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK 3