Lomeguatrib
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3106174 | Sigma-Aldrich | 25 MG | 4680 | 请咨询 |
| 3106174 | Sigma-Aldrich | 5 MG | 1340 | 请咨询 |
| 4176920 | Fluorochem | 1g | 23320 | 请咨询 |
| 4176920 | Fluorochem | 250mg | 9700 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C10H8BrN5OS |
| Molecular weight | 326.17 |
| MDL number | MFCD23703756 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825566 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Lomeguatrib is a highly potent inactivator of O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein which can confer resistance to some cancer chemotherapeutics, in particular the DNA alkylating agents such as Temozolomide, DTIC, Carmustine, etc. Lomeguatrib is a highly potent inactivator of MGMT and can be used to further investigate mechanisms of resistance. It is a potent irreversible inactivator of all mammalian O6-alkylguanine-DNA-alkyltransferases, so far tested with nanomolar activity in vitro and in vivo. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | room temp |
| SMILES string | Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1 |
| InChI | 1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16) |
| InChI key | JUJPKFNFCWJBCX-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |