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MJ33 锂盐

MJ33 lithium salt

CAS NO：

规格：	powder, ≥90% (NMR)

包装规格：

5 MG

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产品价格

产品编号	品牌	包装单位	单价(元)	现货
3139096	Sigma-Aldrich	5 MG	2950	请咨询

结构式

基本信息

Empirical Formula【经验(实验)分子式】	C₂₂H₄₃F₃O₆PLi
Molecular weight	498.48
MDL number	MFCD03787978
PubChem Substance ID【PubChem化学物质编号】	24278549
NACRES	NA.77
Application【应用】	MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor: to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia to study its potential use as a therapeutic agent
Biochem/physiol Actions【生化/生理作用】	MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate. Novel, active site directed, specific, competitive and reversible inhibitor of phospholipase A₂ (PLA₂).

产品性质

Quality Level【质量水平】	100
Assay【测定】	≥90% (NMR)
form【形式】	powder
color【颜色】	white to beige
solubility【溶解性】	H₂O: ≥5 mg/mL (warmed at 60 ℃)
storage temp.【储存温度】	2-8℃
SMILES string	CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+]
InChI	1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1
InChI key	GDLMLQJISATCEL-UHFFFAOYSA-M
packaging【包装】	5 mg in glass bottle

安全信息

Storage Class Code【储存分类代码】	13 - Non Combustible Solids
WGK	WGK 3
Personal Protective Equipment【个人防护装备】	Eyeshields, Gloves, type N95 (US)

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