ATR/CDK Inhibitor, NU6027-CAS 220036-08-8-Calbiochem
| CAS NO： | 220036-08-8 |
| 规格： | The ATR/CDK Inhibitor, NU6027, also referenced under CAS 220036-08-8, controls the biological activity of ATR/CDK. This small molecule/inhibitor is primarily used for Cancer applications. |
| 包装规格： | 10 MG |
| 优惠价： | QQ在线咨询在线留言 |
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 4155189 | Sigma-Aldrich | 10 MG | 2930 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C11H17N5O2 |
| Molecular weight | 251.28 |
| MDL number | MFCD05664735 |
| General description【一般描述】 | A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki = 2.5 µM for CDK1, and Ki = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50 = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Peasland, A., et al. 2011., Br J Cancer. 105, 372. Arris, C.E, et al. 2000., J Med Chem.43, 2797. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | red-purple |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear, blue |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |