Pipamperone dihydrochloride

C₂₁H₃₀N₃O₂F · 2HCl

448.40

219-507-5

MFCD00242980

24724576

NA.77

Pipamperone dihydrochloride may be used:

• as an internal standard in liquid chromatography with coulometric detection
• as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
• as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.
D₂ dopamine receptor antagonist; 5-HT₂ serotonin receptor antagonist; antipsychotic.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

100

~99% (HPLC)

powder

white

H₂O: >2.0 mg/mL

Johnson & Johnson

Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3

1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H

BMXXSXQVMCXGJM-UHFFFAOYSA-N

100 mg in poly bottle

GHS07

Warning

H302

Acute Tox. 4 Oral

13 - Non Combustible Solids

WGK 1

dust mask type N95 (US), Eyeshields, Gloves