N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3166567 | Sigma-Aldrich | 25 MG | 8690 | 请咨询 |
| 3166567 | Sigma-Aldrich | 5 MG | 2490 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C19H14Br2N2O3S |
| Molecular weight | 510.20 |
| MDL number | MFCD00355835 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724418 |
| Biochem/physiol Actions【生化/生理作用】 | N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: ~20 mg/mL H2O: insoluble |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Brc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1 |
| InChI | 1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24) |
| InChI key | SJJKUNDBFWUAQB-UHFFFAOYSA-N |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H319 - H413 |
| Precautionary Statements | P273 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 4 - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |