D-erythro-Sphingosine, N-Acetyl--CAS 3102-57-6-Calbiochem
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 4083825 | Sigma-Aldrich | 5 MG | 1790 | 请咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H39NO3 |
| Molecular weight | 341.53 |
| General description【一般描述】 | Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells. Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis of HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A. Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress-activated protein (SAP) kinase in HL-60 human promyelocytic cells. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target Inhibits cell growth and induces apoptosis in HL-60 cells |
| Warning【警告】 | Toxicity: Irritant (B) |
| Preparation Note【制备说明】 | When diluting into aqueous solution, sonication may be necessary to achieve a uniform suspension. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C. |
| Other Notes【其他说明】 | Westwick, J.K., et al. 1995. J. Biol. Chem.270, 22689. Cifone, M.G., et al. 1994. J. Exp. Med.180, 1547. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Bielawska, A., et al. 1993. J. Biol. Chem.268, 26226. Obeid, L.M., et al. 1993. Science259, 1769. Ballou, L.R., et al. 1992. J. Biol. Chem.267, 20044. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem.267, 5048. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (TLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: 25 mg/mL ethanol: 5 mg/mL methanol: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C20H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h15-16,19-20,22,24H,3-14,17H2,1-2H3,(H,21,23)/b16-15+/t19-,20+/m0/s1 |
| InChI key | BLTCBVOJNNKFKC-QUDYQQOWSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |