PD-118057
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3179583 | Sigma-Aldrich | 25 MG | 8920 | 请咨询 |
| 3179583 | Sigma-Aldrich | 5 MG | 3050 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C21H17Cl2NO2 |
| Molecular weight | 386.27 |
| MDL number | MFCD08705328 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724580 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure |
| Features and Benefits【特点和优势】 | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | light yellow |
| solubility【溶解性】 | DMSO: 9 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | OC(=O)c1ccccc1Nc2ccc(CCc3ccc(Cl)c(Cl)c3)cc2 |
| InChI | 1S/C21H17Cl2NO2/c22-18-12-9-15(13-19(18)23)6-5-14-7-10-16(11-8-14)24-20-4-2-1-3-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26) |
| InChI key | ZCQOSCDABPVAFB-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 - H413 |
| Precautionary Statements | P273 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |