Polo-like Kinase Inhibitor V, Poloxin-CAS 321688-88-4-Calbiochem
| CAS NO： | 321688-88-4 |
| 规格： | The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| 包装规格： | 5 MG |
| 优惠价： | QQ在线咨询在线留言 |
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 4084139 | Sigma-Aldrich | 5 MG | 2570 | 请咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H19NO3 |
| Molecular weight | 297.35 |
| MDL number | MFCD00534351 |
| General description【一般描述】 | A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Reindl, W., et al. 2008. Chem Biol.15, 459. Yuan, J., et al. 2011, Am J Pathol179, 2091. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 25 mg/mL, clear, yellow |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |