LM22A-4
产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3106157 | Sigma-Aldrich | 25 MG | 4550 | 请咨询 |
| 3106157 | Sigma-Aldrich | 5 MG | 1310 | 请咨询 |
| 4176927 | Fluorochem | 1g | 27910 | 请咨询 |
| 4176927 | Fluorochem | 250mg | 11170 | 请咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H21N3O6 |
| Molecular weight | 339.34 |
| NACRES | NA.77 |
| Application【应用】 | LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates. |
| Biochem/physiol Actions【生化/生理作用】 | LM22A-4 is a non-peptide and shares similarity with brain-derived neurotrophic factor (BDNF), especially in the loop2 region. It improves oligodendroglia density and favors myelin repair. LM22A-4 elevates the expression of protein kinase B (PKB or Akt) and extracellular signal-regulated kinases (ERKs). LM22A-4 elicits neuroprotection in spinal cord injury (SCI) by deregulating the cleaved-caspase-3 and favoring B-cell lymphoma 2(Bcl-2) expression. LM22A-4 is a partial agonist of TrkB, a brain-derived neurotrophic factor (BDNF) receptor. In binding assays, LM22A-4 displaces BDNF with an IC50 of 47 nM. The compound restores TrkB phosphorylation and respiratory function in a mouse model of Rett syndrome. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |