产品价格
| 产品编号 | 品牌 | 包装单位 | 单价(元) | 现货 |
| 3177587 | Sigma-Aldrich | 1 MG | 3800 | 请咨询 |
| 3177587 | Sigma-Aldrich | 100 μG | 1119 | 请咨询 |
结构式
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基本信息
| Empirical Formula【经验(实验)分子式】 | C25H36O4 |
| Molecular weight | 400.55 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825909 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets. |
| Other Notes【其他说明】 | Light and air sensitive. |
产品性质
| biological source【生物来源】 | (from Biopolaris leersia fungal metabolite) |
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | protect from light |
| color【颜色】 | white to beige |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | [H]C(/C1=C/C[C@]([C@]2(O[C@@H](C=C(C)C)C[C@@H]2C)CC3)([H])[C@@]3(C)C[C@@]([C@](C)(O)C4)([H])[C@]1([H])C4=O)=O |
| InChI | 1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16-,18-,19-,21+,22+,23+,24+,25-/m0/s1 |
| InChI key | MWYYLZRWWNBROW-BDZRSQQBSA-N |
| packaging【包装】 | 1 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |