1,1-二甲基-4-苯基哌嗪碘化物

1,1-Dimethyl-4-phenylpiperazinium Iodide
CAS NO:54-77-3
规格:≥98% (TLC or titration)
包装规格:1 G,10 G
优惠价:QQ在线咨询在线留言
产品价格
产品编号品牌包装单位单价(元)现货
3356921Sigma-Aldrich1 G754请咨询
3356921Sigma-Aldrich10 G3550请咨询
结构式
基本信息
Empirical Formula【经验(实验)分子式】
C12H19IN2
Molecular weight
318.20
Beilstein
3746109
EC number【EC 号】
200-213-0
MDL number
MFCD00011976
PubChem Substance ID【PubChem化学物质编号】
24277832
NACRES
NA.77
Application【应用】
1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:
  • to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
  • to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
  • to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

Biochem/physiol Actions【生化/生理作用】
1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.
Features and Benefits【特点和优势】
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
Quality Level【质量水平】
200
Assay【测定】
≥98% (TLC or titration)
mp
234-238 ℃ (lit.)
solubility【溶解性】
H2O: 21 mg/mL
storage temp.【储存温度】
−20℃
SMILES string
[I-].C[N+]1(C)CCN(CC1)c2ccccc2
InChI
1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
InChI key
XFZJGFIKQCCLGK-UHFFFAOYSA-M
Gene Information
human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)
rat ... Chrna2(170945), Chrna3(25101), Chrna4(25590), Chrnb2(54239), Chrnb4(25103)
packaging【包装】
1, 10 g in glass bottle
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
留言咨询
关闭
*姓名:
*电话:
*单位:
*Email:
*标题:
*留言内容:
*验证码: