Cromakalim

CAS NO:94470-67-4
包装规格:10 MG,50 MG
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产品价格
产品编号品牌包装单位单价(元)现货
3072759Sigma-Aldrich10 MG2730请咨询
3072759Sigma-Aldrich50 MG8880请咨询
结构式
基本信息
Empirical Formula【经验(实验)分子式】
C16H18N2O3
Molecular weight
286.33
MDL number
MFCD00133201
PubChem Substance ID【PubChem化学物质编号】
24891962
NACRES
NA.77
Application【应用】
Cromakalim has been used:
  • as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
  • as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
  • as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

Biochem/physiol Actions【生化/生理作用】
Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.
Features and Benefits【特点和优势】
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
Quality Level【质量水平】
200
storage temp.【储存温度】
2-8℃
SMILES string
CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N
InChI
1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
InChI key
TVZCRIROJQEVOT-CABCVRRESA-N
Gene Information
rat ... Kcna1(24520), Kcnj1(24521), Kcnj5(29713), Kcnj8(25472)
packaging【包装】
10, 50 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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